Duff's surname, "Killigan," is cemented canonically as a parody of "Gilligan" ("Gilligan's Island"), "gill" - "kill" perhaps, morosely, reflecting his violent tendencies, as killing is a superlative example of a violent tendency. "Killigan" - "kill again" is another proposed explanation, since, as a supervillain, his recidivism rate is through the roof. As well, his name, moniker or pseudonym, "Duff," is a reference to golf culture; Duff means, in pith, "bad golfer," and certainly Duff Killigan would be considered a (morally) bad golfer.
Confidence: 75